| 1. | SIMULTANEOUS DETERMINATION OF MONTELUKAST SODIUM AND BAMBUTEROL HYDROCHLORIDE IN TABLET DOSAGE FORM BY ULTRAVIOLET SPECTROPHOTOMETRY | | Pushpa Latha E*, Abiram L
Shanthiram College of Pharmacy, Nandyal, Kurnool (Dist), A.P. | |
|
|
ABSTRACT
A simple, accurate, and precise dual wavelength spectrophotometric method was developed for simultaneous determination of Montelukast Sodium (MTKT) and Bambuterol Hydrochloride (BAM) in combined pharmaceutical dosage forms. The method based on determination of MTKT at 322.0 nm using its absorptivity value and BAM at 266.0 nm after deduction of absorbance due to MTKT. The two drugs follow Beer-Lambert’s law over the concentration range of 1-10 μg/mL for MTKT and 5-40 μg/mL for BAM. The recovery of the MTKT and BAM were found to be 99.87 ± 1.13 & 99.87 ± 1.13100 %. Validation of the proposed methods was carried out for its accuracy, precision, specificity and ruggedness according to ICH guidelines. The proposed methods can be successfully applied in routine work for the determination of MTKT and BAM in combined dosage form.
KEY WORDS: Montelukast sodium, Bambuterol hydrochloride, UV Spectrophotometric method.
|
| 2. | EFFECT OF ADIANTUM CAUDATUM IN STREPTOZOTOCIN INDUCED DIABETES MELLITUS IN RATS | | Dipankar Saha*1, Ghosh S.K.2, Trishna Das1, Habibur Rahman3
1Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati Assam
2. Department of Pharmacy, Dibrugarh University, Dibrugarh, Assam
3Anurag Pharmacy College, Ananthagiri (V), Kodad, Nalgonda (Dist.), A.P-508206 | |
|
|
ABSTRACT
The alleged anti-diabetic potential of ethanolic extract of Adiantum caudatum (Convolvulaceae) whole plant, on fasting blood sugar levels and serum biochemical analysis in Streptozotocin induced diabetic rats were investigated. Ethanolic Extract of Adiantum caudatum produced a significant anti-diabetic activity at dose levels 1/10 of their lethal doses (2000 mg/kg b.w).The activity was found comparable with standard drug Glibenclamide. The present investigation of the plant established some pharmacological evidence to support the folklore claim.
KEY WORDS: Adiantum caudatum, Streptozotocin (STZ), Antidiabetic effect
|
| 3. | EVALUATION OF ANTHELMINTIC ACTIVITY OF STRYCHNOS POTATORUM SEEDS | | Jayasri P*, Mulla Mohammed Gouse, Mulla Shaiksh Avali, Syed Dadavali
Department of Pharmacognosy, Safa College of Pharmacy, Tandrapadu, Kurnool, Andhra Pradesh, India-518562. | |
|
|
ABSTRACT
The present study was designed to explore the anthelmintic activity of different extracts of seeds of Strychnos potatorum using petroleum ether, ethyl acetate methanol and water as solvents. Various concentrations (25 and 50mg/ml) of all the extracts were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Albendazole as standard reference and normal saline as control. The study indicated the potential usefulness of Strychnos potatorum against earthworm infections.
KEY WORDS: Anthelmintic activity, Strychnos potatorum, Albendazole
|
| 4. | PHYTOCHEMICAL EVALUATION OF CHLORIS BARBATA LEAVES | | Elumalai A*, Chinna Eswaraiah M, Swapna P
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (v), Kodad (M), Nalgonda (Dt), Andhra Pradesh, India, 508 206. | |
|
|
ABSTRACT
The leaves of Chloris barbata leaves were collected locally, shade dried and extracted with water, ethanol, methanol, acetone, chloroform, benzene and petroleum ether by using Soxhlet apparatus. The yields of different extracts of leaves were 3.6%, 8.4%, 12.5%, 1.9%, 1.2%, 0.9% and 2.6% respectively. The preliminary phytochemical screening was carried out for the presence of alkaloids, flavonoids, carbohydrate glycosides, tannins, and saponins for different extracts of Chloris barbata (leaves). The physiochemical evaluation was carried out for the determination of ash values, includes total ash, acid insoluble ash and water-soluble ash, and moisture content, extractive values and fluorescence analysis for leaves of Chloris barbata.
KEY WORDS: Chloris barbata, total ash, acid insoluble ash, water-soluble ash, phytochemical screening
|
| 5. | HEPATOPROTECTIVE ACTIVITY OF ECBOLIUM VIRIDE (FORSK.) ALST. (ACANTHACEAE) ON EXPERIMENTAL LIVER DAMAGE IN RATS | | Preethi Priyadharshni S.P*, T.Satyanarayana, B.Ganga Rao, Rajesh.K
A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India | |
|
|
ABSTRACT
The Methanol extract of Ecbolium viride (Forsk.) Alst. (Acanthaceae), was tested for hepatoprotective activity against carbon tetrachloride and paracetamol-induced hepatotoxicity in rats. Ecbolium viride (Forsk.) Alst. (Acanthaceae), exhibited significant hepatoprotective activity by reducing carbon tetrachloride and paracetamol-induced change in bio-chemical parameters that was evident by enzymatic examination. The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the LD50 value is more than the dose of 5 g/kg body wt.
KEY WORDS: Ecbolium viride (Forsk.) Alst. (Acanthaceae), Carbon tetrachloride; Paracetamol
|
| 6. | EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF CALOTROPIS GIGANTEAN, TYLOPHORA INDICA AND SARCOSTEMMA SECOMONE | | Ravikumar A1*, Abbulu K2
1PG &Research Dept. of Pharmacognosy, Bapatla College of Pharmacy, Bapatla-522 101, INDIA
2PG & Research Dept. of Pharmacognosy, Geetanjali College of Pharamcy, Hyderabad 501 301, INDIA | |
|
|
ABSTRACT
The main objective of the present investigation is to evaluate the anti-inflammatory property of Calotropis gigantean, Tylophora indica and Sarcostemma secomone in Wister rats using the Carrageenan induced left hind paw edema. In the study it was observed that the aqueous, ethanol and chloroform extracts were significantly inhibit paw edema induced by carrageenan in rats. The ethanolic extract showed a significant anti-inflammatory property when compared with the aqueous, chloroform, standard and untreated control. Among the three tested plant species S.sarcostemma showed the maximum inhibition in rats.
KEY WORDS: Calotropis gigantean, Tylophora indica, Sarcostemma secomone, anti-inflammatory, Carrageenan.
|
| 7. | ISOLATION OF PHYTOCHEMICAL CONSTITUENTS FROM STEM BARKS OF MADHUCA LONGIFOLIA | | Chinna Eswaraiah M1*, Elumalai A1, Habibur Rahman2
1Dept. of Pharmacognosy, 2Dept. of Pharmacology, Anurag Pharmacy College, Ananthagiri (V), Kodad (M), Nalgonda (Dt), Andhra Pradesh, India, 508 206. | |
|
|
ABSTRACT
The stem barks of Madhuca longifolia (Sapotaceae,) are reported to be of great medicinal importance. Isolation of chemical constituents was carried out from the leaves of Madhuca longifolia, an evergreen member of the family Sapotaceae, using column chromatography. Identification of chemical constituents was done by coloumn chromatography, IR and NMR techniques. Five compounds ie β-amyrin acetate, 21-Hydroxy-3-oleanyl myricitate, Ursolic Acid, n-hexyl-3-acetyl betulinate and 3-(27-Carboxy oleanyl) – Octanate were isolated from the ethyl acetate extracts. These findings are useful in establishing a relationship between chemical composition of the stem bark extract and previously reported activities of Madhuca longifolia and also may assign a new potential role of Madhuca longifolia extract in human health care.
KEY WORDS: Madhuca longifolia, Chemical constituents, Column chromatography, IR, NMR
|
| 8. | SPECTROPHOTOMETRIC QUANTITATION OF SULFAMETHOXAZOLE IN BULK DRUG AND PHARMACEUTICAL FORMULATION USING MULTIVARIATE TECHNIQUE | | Pushpa Latha E*, Nagendra Kumar Guptha CV, Abiram L
Shanthiram College of Pharmacy, Nandyal, Kurnool (Dist), A.P. | |
|
|
ABSTRACT
A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of sulfamethoxazole in bulk and pharmaceutical formulation has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelengths. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise (% recovery r = ) and linear within the range μg/ml. There was no interference from the excipients. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions.
KEY WORDS: UV Spectrophotometry, sulfamethoxazole, pharmaceutical analysis, antimicrobial
|
| 9. | 2 - PYRAZOLINE: A PHARMACOLOGICALLY ACTIVE MOIETY | | Dipankar B.1*, Hirakmoy C.2, Asish B.1, Abhijit C.1
1 C.L.Baid Metha College of Pharmacy, Thoraipakkam ,Chennai-600097
2 V.L.College Pharmacy ,Raichur , Karnataka-584103 | |
|
|
ABSTRACT
The aim of this review was to collate literature work reported by many researchers on 2-pyrazoline derivatives for their varoius pharmacological activities and also to report the recent efforts made on this moiety. This interesting group of compound has diverse biological activities such as antimicrobial, antimyobacterial, antiamoebic, antiviral, antihelminthic, antiparasitic, insecticidal, anti-inflammatory, analgesic, anticonvulsant, antidepressant, anticancer, anaesthetic, antidiabetic, antioxidant, ACE inhibitory, hypotensive, cholesterol inhibitory and selective activity such as Nitric oxide synthase (NOS) inhibitor and Cannabinoid CB1 receptor antagonists activity. The purpose of this review is to provide an overview of diverse pharmacological activities of 2-pyrazoline moiety. Various derivatives of 2-pyrazoline have been analysed in this review for varying pharmacological activities.
KEY WORDS: 2-Pyrazoline derivatives, analgesic, anti-inflammatory, anticancer, anticonvulsant, antimicrobial, antimycobacterial.
|
| 10. | ANALYSIS OF BIOLOGICAL SAMPLE BY LC-MS/MS: A COMPLETE REVIEW | | Hirakmoy C.*1, Dipankar B.2, Asish B.2, Abhijit C.2
1Dept. of Quality Assurance, V.L. College of Pharmacy, Raichur-584103, Karnataka.
2C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai. | |
|
|
ABSTRACT
Biological sample analysis is an important aspect of medicinal product development for drug containing new active substances as well as generic products to get complete pharmacokinetic and toxicological profile which supporting the safety and efficacy of the drug substance or product. This study is mandatory, because it support new applications for drug approval by various respective regulatory authorities. As the sample concentration in biological matrix is very low, Hence LC-MS/MS is chosen as main instrument in this article, which support the analysis for quantitative application. This article provide complete review on the analysis of sample by proper selective biological matrix, sensitive analytical methods , recent advances in sample preparation and basic idea to select suitable technique for preparation of sample. It also provides a fundamental idea for assessing the reliability and overall performance of a bioanalytical method by validating the LC-MS/MS method based on various guidelines. Further various regulatory aspect of validation is also discussed in this paper.
KEY WORDS: Biological sample, Bioanalytical method development, Validation, LC-MS/MS, Extraction.
|
| 11. | A SHORT REVIEW ON THERAPEUTIC USES OF COUROUPITA GUIANENSIS AUBL | | Chandolu Sai Kumar*, Gaddala Naresh, Vanamala Sudheer, Naresh Veldi, A. Elumalai
Anurag Pharmacy College, Ananthagiri (v), Kodad (M), Nalgonda (Dt), Andhra Pradesh, India, 508 206. | |
|
|
ABSTRACT
Medicinal plants are used as traditional form of providing relief to several diseases. Presently, millions of adults are depending on medicinal plants for their primary health care needs. Couroupita guianensis (Family: Lecythidaceae; Brazil-nut family), is an ever green tree native to tropical northern South America, Southern Caribbean and India. In India, it has religious significance and can be seen in Shiva temples and known as Mallikarjuna flowers in Telugu. Its common name includes Ayahuma, cannon-ball tree (cannon-ball-like fruits). It is very rare and lesser exploited from ethno pharmacology point of view. This review will be helpful to create interest towards Couroupita guianensis and may be useful in developing new formulations with more therapeutic and economical value.
KEY WORDS: Couroupita guianensis, Lecythidaceae
|
| 12. | A PHYTO-PHARMACOLOGIGAL REVIEW ON STRYCHNOS POTATORUM LINN | | Venkatesh A*, Silambujanaki P
Department of Pharmacology, SRM College of Pharmacy, Kattankulathur, Kancheepuram Dt, Tamil Nadu, India, 603 319. | |
|
|
ABSTRACT
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. This review will be helpful to create interest towards Strychnos potatorum and may be useful in developing new formulations with more therapeutic and economical value.
KEY WORDS :Strychnos potatorum, medicinal, pharmacological importance
|
|
|