A simple, rapid, accurate, precise and economical UV-spectrophotometric method have been developed and validated for simultaneous estimation of Mupirocin and MometasoneFuroate in a Pharmaceutical dosage form. The Q absorbance ratio method, which involves formation of Q-absorbance equation at 226 nm (isoabsorptive point) and also at 220 nm (λmax of Mupirocin).Developed methods were validated according to ICH Q2 (R1) guidelines. The methods were found to be linear between the range of 5 - 25 µg/ml for MometasoneFuroate and Mupirocin. The precision (intra-day, inter-day) of method were found within limits (RSD <2%). Accuracy was determined by recovery studies and showed % recovery between 98 to 102%.

Periodontal diseases is the dental diseases associated with the mouth infection. Basically gingivitis grow to form the periodontal disease. It infects the periodontal pocket.so overcome this type of diseases, now a days periodontal chip are used. These are polymeric chips containing active pharmaceutical ingredient with base materials which protect the pocket from infection. Various kinds of periodontitis can be cured by the means of periodontal chip. Mainly tetracyclines are used as antimicrobial agent in chip with suitable excipients. Chip can be prepared by solvent casting method. Chip is mainly advantageous for those drugs whom systemic administration is not suitable. So by this way desired release of drug can gated with good acceptance from patient.

This study was aimed to formulate and characterize a novel coprocessed excipient (Povilent) from processed Lentinus tuber regium (LTR) and polyvinylpyrollidone (PVP) to improve the flowability and compressibility of LTR. Povilent was produced by blending and co-drying alcoholic dispersions of LTR and PVP powders (70: 30 % w/w). The physico-technical properties of the new powder namely: bulk, tapped and particle densities, angle of repose, flow rate, Carr’s index, Hausner’s ratio, pH, swelling index, hydration capacity and dilution potential were determined in comparison with those of the natural and processed powders of LTR. Results show that the bulk and tapped densities increased insignificantly from the natural to the coprocessed excipients (Povilent> Processed LTR >Natural LTR) (P>0.05) while those of the particle density was very significant (P<0.05). On the other hand, the angle of repose, Carr’s index, Hausner’s ratio and porosity decreased from the natural to the coprocessed excipients (Natural LTR > Processed LTR >Povilent) (P<0.05).  Swelling index was in the order: Natural LTR >Povilent> Processed LTR, though insignificant (P>0.05), while the hydration capacity took the order: Natural LTR > Processed LTR >Povilent (P<0.05). Povilent has a dilution potential of 70-90% (paracetamol), 20-30% (ascorbic acid and metronidazole) respectively. The compacts prepared from both the processed or natural LTR were very friable. Flowability was highly improved in Povilent than the processed powder alone, the natural form not flowable.This shows that the flowability and compressibility of LTR was highly improved by coprocessing it with PVP.